Background: Rheumatic fever is a preventable chronic disease preceded by group A beta-hemolytic streptococcus (GABHS). OBJECTIVE: To test the non-inferiority of once-daily (QD) oral amoxicillin to the recommended twice-daily (BID) oral penicillin V in GABHS pharyngitis. DESIGN: Randomised non-inferiority trial. SETTING: School-based clinic in New Zealand. Patients: Children presenting with GABHS pharyngitis. INTERVENTIONS: Children were randomised to oral amoxicillin 1500mg BID (or 750mg if bodyweight was



Auckland, New Zealand
New Zealand

Institution name: University of Auckland
Authors: Lennon DR Fracp, Farrell E Mhsc, Martin DR Phd, Stewart JM Msc.
Journal Name: Arch Dis Child.
Data: 2008, Mar 12
Country: New Zealand