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Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Par
Plethoras of CNS-active drugs fail to effect their pharmacologic response due to their in vivo inability to cross the blood-brain barrier (BBB).
Minneapolis, MN 55455 USA Levodopa is the gold standard drug for the symptomatic control of Parkinson's disease (PD).
Nantes, France France Parkinson's disease (PD), one of the most common human neurodegenerative disorders, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain.
Osaka, Japan Japan Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations.
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Boston, MA 02118 USA OBJECT: Since the initial 1991 report by Tsubokawa et al., stimulation of the M1 region of cortex has been used to treat chronic pain conditions and a variety of movement disorders.
Burlington, MA 01805 USA Parkinson's disease (PD) is a neurodegenerative disorder which leads to severe movement impairment; however, Parkinsonian patients frequently suffer from gastrointestinal (GI) problems which at present are poorly understood, scarcely investigated, and lack an effective cure.
Pisa, Italy Italy The concept that everything can die, but nothing can regenerate in the brain has been replaced with new hope that stem cells will provide avenues to repair the damaged central nervous system (CNS).
London, UK UK Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-ne
BACKGROUND: There is an urgent need for therapies that slow or reverse the progression of Parkinson's disease (PD). Neurotrophic factors can improve the function of degenerating neurons and protect against further neurodegeneration, and gene transfer might be a means to deliver effectively these factors to the brain.
San Francisco, CA USA OBJECTIVES: In patients with advanced Parkinson disease, levodopa/carbidopa formulated as a gel suspension (Duodopa) permits continuous delivery into the small intestine using a portable pump, resulting in less variability in levodopa concentrations and fewer motor fluctuations and dyskinesias than with oral levodopa administration.
Uppsala, Sweden Sweden This pilot study examines the effects of Tai Chi on balance, gait and mobility in people with Parkinson disease (PD).
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