Melanoma

Favorable outcome in clinically stage II melanoma patients is associated with the presence of activa
In this study we investigated whether the presence of specific populations of tumor infiltrating lymphocytes (TILs) in diagnostic primary melanoma biopsies are related to outcome in clinically stage II melanoma patients.

Amsterdam, The Netherlands
The Netherlands
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression
Although many melanomas harbor either activating mutations in BRAF or NRAS, there remains a substantial, yet little known, group of tumors without either mutation.
3601 Spruce Street
Philadelphia, PA 19104
USA
Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III me
BACKGROUND: Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment.

Rotterdam, The Netherlands
The Netherlands
Favorable outcome in clinically stage II melanoma patients is associated with the presence of activa
In this study we investigated whether the presence of specific populations of tumor infiltrating lymphocytes (TILs) in diagnostic primary melanoma biopsies are related to outcome in clinically stage II melanoma patients.

Amsterdam, The Netherlands
The Netherlands
Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III me
BACKGROUND: Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment.

Rotterdam, The Netherlands
The Netherlands
A large cohort study of nonsteroidal anti-inflammatory drug use and melanoma incidence
Results of laboratory studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may have chemopreventive activity and therapeutic efficacy against melanoma.
2000 Broadway
Oakland, CA 94612
USA
Effect of multiple-nodal basin drainage on cutaneous melanoma
HYPOTHESIS: The number of nodal basins draining a primary cutaneous melanoma is not an independent predictor of outcome.

Louisville, KY 40292
USA
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival
Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key strategy for the development of new drugs.

Newcastle upon Tyne,
UK
Effect of multiple-nodal basin drainage on cutaneous melanoma
HYPOTHESIS: The number of nodal basins draining a primary cutaneous melanoma is not an independent predictor of outcome.

Louisville, KY 40292
USA
Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism
The unresponsiveness of metastatic melanoma to conventional chemotherapeutic and biological agents is largely due to the development of resistance to apoptosis.

Rome, Italy
Italy