Lupus

Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regul
OBJECTIVE: CD4+,CD25high regulatory T (Treg) cells play a crucial role in the maintenance of self tolerance and prevention of organ-specific autoimmunity.

Heidelberg, Germany
Germany
Efficacy and safety of TNF-blocker therapy in systemic lupus erythematosus
BACKGROUND: There is still unmet medical need in the therapy of severe organ manifestations of patients with systemic lupus erythematosus (SLE).
Fetscherstrasse 74
Dresden, Germany 01307
Germany
[Sjögren's syndrome associated with childhood-onset systemic lupus erythematosus]
Sjögren syndrome (SS) is a common autoimmune disease that exhibits broad organ-specific and systemic manifestations, the most prevalent being decreased lacrimal and salivary gland function, xerostomia, and keratoconjunctivitis sicca.

Yokohama, Japan
Japan
Anti-histones antibodies in systemic lupus erythematosus: prevalence and frequency in neuropsychiatr
To investigate the specificity, sensitivity, and concomitant presence of antibodies against histones (H), histone H1 (H1), and histone H3 (H3) in patients with systemic lupus erythematosus (SLE) and analyze their association with SLE.

Beijing, China
China
Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythemato
OBJECTIVES: To determine the frequency and characteristics of clinical signs, symptoms, laboratory findings, and medication use in children with pediatric systemic lupus erythematosus (pSLE) at presentation and during the course of the disease, and to examine correlations among disease manifestations, disease activity, and damage over time.

Toronto, Ontario
Canada
Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease
Hematopoietic stem cells (HSCs) have the capacity for self-renewal and the potential to differentiate into all types of hematopoietic and immune system cells.

Bethesda, MD
USA
Fulvestrant (faslodex), an estrogen selective receptor downregulator, in therapy of women with syste
OBJECTIVE: Estrogen plays a role in the activation of systemic lupus erythematosus (SLE) and in upregulating intracellular signals by binding to the estrogen receptor(s).

Kansas City, MO, Pittsburgh, PA
USA
Lupus: improving long-term prognosis
AbstractOver recent decades short- and medium-term survival has greatly improved in patients affected with systemic lupus erythematosus, but long-term prognosis still remains poor mainly due to complications of the disease and/or its treatment.

Padova, Italy
Italy
Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus
In 15-20% of cases, systemic lupus erythematosus (SLE) presents before the age of 18 years, and such early-onset SLE seems to be particularly severe.

Stanford, CA
USA
Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus a
Objectives. We aimed to test the maternal and fetal outcome of SLE patients who suffered from recurrent spontaneous abortion (RSA) treated with intravenous immunoglobulin (IVIg) alone during pregnancy and whether the clinical response to IVIg treatment is accompanied by modifications of SLE-associated antibodies and of complement levels.

Rome, Italy
Italy