Hyperlipidemia

Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial
OBJECTIVE: To compare the lipid-lowering effects of an alternative regimen (lifestyle changes, red yeast rice, and fish oil) with a standard dose of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin).

Philadelphia, PA
USA
Postprandial triglyceride responses to aerobic exercise and extended-release niacin
BACKGROUND: Aerobic exercise and niacin are frequently used strategies for reducing serum triglycerides, and, yet, there is no information regarding the combined effects of these strategies on postprandial triglycerides.

Auburn, AL
USA
Lowering LDL cholesterol in adults: a prospective, community-based practice initiative
PURPOSE: The purpose of our study was to see if a clinic-wide initiative, with low-density lipoprotein cholesterol (LDL)-lowering interventions, could be an effective health maintenance strategy to decrease LDL levels to <100 mg/dL in a community-based, internal medicine outpatient setting.

Portland, OR
USA
The effect of orlistat and ezetimibe, alone or in combination, on serum LDL and small dense LDL chol
BACKGROUND: Increased concentrations of low density lipoprotein cholesterol (LDL-C), as well as of small dense LDL-C (sdLDL-C), are considered as cardiovascular risk factors.

Ioannina, Greece
Greece
A national study on lipid management
BACKGROUND: Hyperlipidemia remains a major cause of morbidity in Western countries.

Beer Sheva, Israel
Israel
Effect of almonds on insulin secretion and insulin resistance in nondiabetic hyperlipidemic subjects
Nuts appear to have a marked effect in cohort studies in reducing the risk of coronary heart disease (CHD), but their demonstrated ability to lower cholesterol can only explain a proportion of the reduction in risk.

Toronto, Ontario
Canada
Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular disease
n-3 Fatty acids (FAs) when used in doses of 3-4 g/d eicosapentaenoic acid and docosahexaenoic acid have profound effects on triacylglycerol (TG) concentrations.

Atlanta, GA 30303
USA
Predictors of uncontrolled hyperlipidaemia in high-risk ambulatory patients in primary care
OBJECTIVE: To determine (a) the proportion of patients at high risk of cardiovascular events who achieve low-density lipoprotein cholesterol (LDL-C) goals as recommended by the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) guidelines, and (b) the predictors of poor LDL-C control.

Munich, Germany
Germany
Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
PURPOSE OF REVIEW: Stearoyl-coenzyme A desaturase 1 is a delta-9 fatty acid desaturase that catalyzes the synthesis of monounsaturated fatty acids and has emerged as a key regulator of metabolism.

Madison, WI 53706
USA
Emerging lipid-lowering drugs: squalene synthase inhibitors
BACKGROUND: Lapaquistat was the only squalene synthase inhibitor in Phase III clinical trials in Europe and the United States, but was recently discontinued from clinical development.

Monroe, LA 71209
USA