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Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression asso
PURPOSE: Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells.
Lausanne, Switzerland Switzerland miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiatio
BACKGROUND: Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy.
San Francisco, CA USA Several years ago, the discovery of a highly tumorigenic subpopulation of stem-like cells embedded within fresh surgical isolates of malignant gliomas lent support to a new paradigm in cancer biology--the cancer stem cell hypothesis.
44 Binney Street
Boston, MA 02115 USA The evaluation of primary brain tumor is challenging.
Los Angeles, CA USA The failure of current glioma therapies is mainly due to the ability of the tumor cells to invade extensively the surrounding healthy brain tissue, hence escaping localized treatments.
Singapore, China Brain tumors are generally incurable cancers.
555 University Ave
Toronto, Ontario Canada Medulloblastoma and other embronal brain tumors are similar in appearance and differentiation potential to neural stem and progenitor cells.
Baltimore, MD 21205 USA Despite maximal therapy, malignant gliomas have a very poor prognosis.
221 Sands Building
Durham, NC 27710 USA Primary malignant brain tumors account for 2 percent of all cancers in U.S. adults.
6901 Bertner Avenue
Houston, TX 77030 USA Temozolomide in newly diagnosed malignant gliomas: administered concomitantly with radiotherapy, and
BACKGROUND: Surgical resection followed by radiotherapy used to be the standard treatment in malignant gliomas.
Lansing, MI USA |
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