Alzheimer's Disease

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo
BACKGROUND: Immunisation of patients with Alzheimer's disease with full-length amyloid-beta peptide (Abeta(42)) can clear amyloid plaques from the brain.

Southampton, UK
UK
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patien
BACKGROUND: Although treatments for Alzheimer's disease sometimes improve cognition, functional ability, or behaviour compared with baseline levels, such improvements are inconsistent across studies and measures, and effects diminish over time.

Houston, TX
USA
Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.
OBJECTIVE: To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD).
3599 Rainbow Blvd, MSN 2012
Kansas City, KS 66160
USA
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study.
OBJECTIVE: To determine whether beta-amyloid (Abeta) peptides segregated into distinct biochemical compartments would differentially correlate with clinical severity of Alzheimer disease (AD).
630 W 168th St, P&S Box 16
New York, NY 10032
USA
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk
Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition.
North Shore-LIJ
Manhasset, NY 11030
USA
Network analysis of intrinsic functional brain connectivity in Alzheimer's disease.
Functional brain networks detected in task-free ("resting-state") functional magnetic resonance imaging (fMRI) have a small-world architecture that reflects a robust functional organization of the brain.

Stanford, CA
USA
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor chann
Mutations in presenilins (PS) are the major cause of familial Alzheimer's disease (FAD) and have been associated with calcium (Ca2+) signaling abnormalities.

Philadelphia, PA 19104
USA
Memory impairment and awareness of memory deficits in early-stage Alzheimer's disease.
In addition to their memory impairment, individuals with Alzheimer's disease (AD) often suffer from deficits in self-awareness.

Tokyo, Japan
Japan
Natural products as a robust source of new drugs and drug leads: past successes and present day issu
The history of drug development has its foundation firmly set in the study of natural remedies used to treat human disease over centuries.

Camarillo, CA 93012
USA
Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial.
Numerous clinical studies suggest a link between elevated cholesterol and increased risk of Alzheimer disease (AD), and the preponderance of data suggests that statin therapy may reduce the risk of AD later in life.

Sun City, AZ
USA