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Welcome to the Alzheimer's
Disease File
Patients all over the world
have used the information in The Alzheimer's Disease File since
1992, when the Center for Current Researchone of the first
80 companies on the Internetwas founded. Our highly trained
researchers (all of whom hold Ph.D.s) have searched the advanced
medical database at the National Library of Medicine and compiled
a comprehensive collection of research descriptions on Alzheimer's
Disease and its care.
As you will see, the following research descriptions detail the
findings published in the most respected journals in the field.
Because the research descriptions are written in medical terms,
most people will bring all or parts of the Alzheimer's Disease
File to their doctor for further explanation and discussion.
Often your doctor will have access to full-text articles and
other information that could be useful in planning a successful
course of treatment and prevention. Note that the titles of the
journals are abbreviated according to the National Library of
Medicine's format; your doctor can provide the full title if
you need it.
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hope the information fosters better health.
Sincerely,
Gregory A. Fraser, Ph.D.
Director of ResearchImportant Note: The following information
is provided for your education. It should not be relied upon
for personal diagnosis or treatment. If you believe that a particular
therapy applies to you or someone you care about, be sure to
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Latest Research on
Alzheimer's Disease
PLoS ONE. 2008 Jan 23;3(1):e1475.
No effect of one-year treatment with indomethacin on Alzheimer's disease
progression: a randomized controlled trial.
de Jong D, Jansen R, Hoefnagels W, Jellesma-Eggenkamp M, Verbeek M, Borm G,
Kremer B.
Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen,
The Netherlands.
BACKGROUND: The objective of this study was to determine whether treatment with
the nonselective nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows
cognitive decline in patients with Alzheimer's disease (AD).
METHODOLOGY/PRINCIPAL FINDINGS: This double-blind, randomized,
placebo-controlled trial was conducted between May 2000 and September 2005 in
two hospitals in the Netherlands. 51 patients with mild to moderate AD were
enrolled into the study. Patients received 100 mg indomethacin or placebo daily
for 12 months. Additionally, all patients received omeprazole. The primary
outcome measure was the change from baseline after one year of treatment on the
cognitive subscale of the AD Assessment Scale (ADAS-cog). Secondary outcome
measures included the Mini-Mental State Examination, the Clinician's Interview
Based Impression of Change with caregiver input, the noncognitive subscale of
the ADAS, the Neuropsychiatric Inventory, and the Interview for Deterioration in
Daily life in Dementia. Considerable recruitment problems of participants were
encountered, leading to an underpowered study. In the placebo group, 19 out of
25 patients completed the study, and 19 out of 26 patients in the indomethacin
group. The deterioration on the ADAS-cog was less in the indomethacin group
(7.8+/-7.6), than in the placebo group (9.3+/-10.0). This difference (1.5
points; CI -4.5-7.5) was not statistically significant, and neither were any of
the secondary outcome measures. CONCLUSIONS/SIGNIFICANCE: The results of this
study are inconclusive with respect to the hypothesis that indomethacin slows
the progression of AD. TRIAL REGISTRATION: ClinicalTrials.gov NCT00432081.
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Internist (Berl). 2008 Jan 23 [Epub ahead of print]
[Antidementia drugs - response or non-response?]
[Article in German]
Förstl H.
Klinik und Poliklinik für Psychiatrie und Psychotherapie, TU München, Klinikum
rechts der Isar, Ismaningerstraße 22, 81675, München, Deutschland,
hans.foerstl@lrz.tu-muenchen.de.
Due to the heterogeneous course of illness in individual cases, efficacy or
"treatment-response" can not be measured in single patients; therefore a
clinical distinction between response and non-response is not meaningful.
Constructs which are valid for research projects become misnomers in clinical
practice. To date there are two groups of antidementia drugs, memantine—an NMDA-receptor modulator licensed for the moderate to severe stages—and the
cholinesterase inhibitors donepezil, galantamine, and rivastigmine, licensed for
mild to moderate stages of Alzheimer's disease. These substances exert a
moderate symptomatic effect on cognition and activities of daily living or
clinical global impression, which corresponds to a parallel shift of the natural
course of dementia. A low number of contraindications and few serious adverse
events are the advantages of memantine. The extensive evidence for their
efficacy and safety are the advantages of cholinesterase inhibitors. Symptoms of "cholinopathy" (a severe lack of acetylcholine) predict a favorable
treatment response to cholinesterase inhibitors in groups of demented patients
with attention deficit disorders, fluctuating course of illness, visual
hallucinations, and superimposed states of confusion.
-----
Qual Health Res. 2008 Jan;18(1):31-42.
Losing one's memory in early Alzheimer's disease.
Parsons-Suhl K, Johnson ME, McCann JJ, Solberg S.
Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
A Heideggerian hermeneutical phenomenological research method was used to
investigate the experience of memory loss in twelve individuals with early
Alzheimer's disease or mild cognitive impairment. Data analysis proceeded as
described by Diekelmann, Allen, and Tanner (1989), and incorporated the methods
of Benner (1994), Thomas and Pollio (2002), and van Manen (1990). Three
constitutive patterns with relational themes were identified. The first pattern,
experiencing breakdown, consisted of two themes: awakening to breakdown and
living with forgetting. The second pattern, temporality, consisted of three
themes: being in the nothing, forgetting the past, and looking ahead. The third
pattern, managing forgetting, consisted of the themes: remembering with cues,
writing things down, recognizing what made remembering better or worse, and
using laughter. The finding show that early Alzheimer's disease is more than an
illness of cognitive losses and that forgetting is significant in
light of the meaning that it has within everyday life.
-----
Curr Alzheimer Res. 2007 Dec;4(5):550-2.
Perispinal etanercept for treatment of Alzheimer's disease.
Tobinick E.
Assistant Clinical Professor of Medicine, UCLA, Director, Institute for
Neurological Research, a Private Medical Group, Inc., 100 UCLA Medical Plaza,
Suites 205-210, Los Angeles, California 90095, USA. etmd@ucla.edu.
Background: Increasing basic science and clinical evidence implicates
inflammatory processes and resulting glial activation in the pathogenesis of
Alzheimer's Disease. Excess TNF-alpha, a cytokine with pleotropic effects in the
CNS, has been suggested to be involved in the pathogenesis of AD. In addition to
its pro-inflammatory effects, TNF-alpha affects synaptic transmission; and
glutamate, NMDA, and amyloid pathways. More specifically, TNF-alpha, produced by
glia, has been shown to affect both synaptic strength and to mediate synaptic
scaling, a homeostatic mechanism important to the control of neural networks. A
recently published small, open-label pilot study suggested that inhibition of
the inflammatory cytokine TNF-alpha utilizing the perispinal administration of
etanercept may lead to sustained cognitive improvement for six months in
patients with mild, moderate, and severe Alzheimer's disease. Results: Continued
open-label clinical experience with this new treatment modality, now for more than two years, suggests that weekly maintenance treatment
with perispinal etanercept may have a sustained positive effect. In addition,
rapid clinical improvement, within minutes of dosing, has been observed on a
repeated basis in multiple patients. Discussion: It is hypothesized that
perispinal administration of etanercept may enable rapid delivery to the CNS via
the cerebrospinal venous system, resulting in improvement in synaptic mechanisms
which have been dysregulated by excess TNF-alpha. TNF-alpha modulation in
Alzheimer's disease may also act by influencing glutamate, NMDA, amyloid and
other inflammatory pathways. Methods of perispinal administration, as described
in the pilot study, may prove useful for delivering other therapeutics,
particularly large molecules, to the CNS. Further study in randomized,
placebo-controlled clinical trials and in basic science studies is merited.
-----
Am J Manag Care. 2007 Dec;13 Suppl 8:S198-202.
Current issues in dementia pharmacotherapy.
Daiello LA.
Pharmacotherapy Solutions, 2115 Ivanhoe Rd, Orlando, FL 32804, USA. ldaiello@cox.net
Diagnosis and treatment of dementia in nursing homes and assisted living
facilities remains challenging since response to treatment and disease course
varies for the common degenerative dementias. Four cholinesterase inhibitors and
an N-methyl-D-aspartate glutamate receptor antagonist are approved by the US
Food and Drug Administration for the treatment of Alzheimer's disease (AD).
Treatment with AD medications is clinically efficacious and associated with
reduced caregiver burden. Some controlled trials have reported that
cholinesterase inhibitors and memantine ameliorate dementia-related behavioral
symptoms. Antipsychotic therapy is often used for intractable behavioral
symptoms or psychosis not responding to nonpharmacologic interventions and
antidementia medications; however, the risk/benefit ratio for each patient
should be critically evaluated, because treatment with atypical antipsychotics
has been associated with serious adverse events, including increased risk for death in older adults with dementia.
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Recent Patents CNS Drug Discov. 2007 Nov;2(3):108-87.
Therapeutic treatment of Alzheimer's disease using metal complexing agents.
Price KA, Crouch PJ, White AR.
Department of Pathology and the Centre for Neuroscience, The University of
Melbourne, Victoria 3010 and The Mental Health Research Institute, Parkville,
Victoria 3052, Australia. arwhite@unimelb.edu.au.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by deposition of extracellular amyloid plaques, formation of
intracellular neurofibrillary tangles and neuronal dysfunction in the brain. A
growing body of evidence indicates a central role for biometals such as copper
in many critical aspects of AD. The amyloid beta (Abeta) peptide and its
parental molecule, the amyloid precursor protein (APP) both modulate Cu and Zn
metabolism in the brain. Therefore, aberrant changes to APP or Abeta metabolism
could potentially alter biometal homoestasis in AD, leading to increased free
radical production and neuronal oxidative stress. Modulation of metal
bioavailability in the brain has been proposed as a potential therapeutic
strategy for treatment of AD patients. The lipid permeable metal complexing
agent, clioquinol (CQ), has shown promising results in animal models of AD and
in small clinical trials involving AD patients. Moreover, a new generation of metal-ligand based therapeutics is currently under development. Patents now cover
the generation of novel metal ligand structures designed to modulate metal
binding to Abeta and quench metal-mediated free radical generation. However, the
mechanism by which CQ and other metal complexing agents slows cognitive decline
in AD animal models and patients is unknown. Increasing evidence suggests that
ligand-mediated redistribution of metals at a cellular level in the brain may be
important. Further research will be necessary to fully understand the complex
pathways associated with efficacious metal-based pharmaceuticals for treatment
of AD.
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Consult Pharm. 2007 Sep;22(9):754-62.
The use of cognitive enhancers in behavioral disturbances of Alzheimer's
disease.
Miller LJ.
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA.
lisaj.miller@med.va.gov
OBJECTIVE: To review the literature for double-blind, placebo-controlled trials
that examined the efficacy of cognitive enhancers in the psychopathology of
Alzheimer's disease. DATA SOURCES: Literature searches were conducted using
MEDLINE and EMBASE databases and clinicaltrials.gov. STUDY SELECTION: Overall,
55 articles were reviewed for inclusion. Several open-label studies and case
reports were found on this topic, but only those involving both tacrine and use
of the Neuropsychiatric Inventory were included. Regarding other drugs, only
double-blind, placebo-controlled trials were selected for inclusion. DATA
SYNTHESIS: Limited data suggest that the anticholinesterase inhibitors and
memantine offer an alternative or adjunct to the antipsychotics for the
treatment of moderate-to-severe behaviors. The author reviewed the literature
for pharmacological management of behavioral and psychological symptoms of
dementia (BPSD) using these cognitive enhancers. CONCLUSION: The majority of patients with Alzheimer's disease will experience behavioral disturbances
during the course of their disease. Atypical antipsychotics are used routinely
in these situations to treat the psychotic features and agitation. However,
atypicals now carry a "black box" warning issued by the Food and Drug
Administration on the basis of evidence that their use in geriatric patients
with dementia-related psychosis may put patients at increased risk of mortality
as a result of cardiovascular or infectious events. An alternative to the
atypicals may be the acetylcholinesterase inhibitors and memantine, which have
been shown to stabilize cognitive as well as behavioral issues in patients,
utilizing the "gold standard" for behavior, the Neuropsychiatric Inventory.
Efficacy varies among agents, with the greatest positive effects seen with
donepezil, which also has the greatest number of studies. Drug benefits were
harder to demonstrate for mild-to-moderate BPSD compared with moderate-to-severe
symptoms.
-----
Int J Geriatr Psychiatry. 2007 Sep 26; [Epub ahead of print]
A 2-year follow-up of 233 very mild (CDR 0.5) Alzheimer's disease
patients (REAL.FR cohort).
Nourhashemi F, Ousset PJ, Gillette-Guyonnet S, Cantet C, Andrieu S, Vellas B.
CHU Toulouse, Hopital Casselardit, Service de medecine interne et gerontologie
clinique, Toulouse, France.
OBJECTIVES: Making an early diagnosis of Alzheimer's Disease (AD) is becoming
increasingly important. The Clinical Dementia Rating scale (CDR), a
semi-structured interview with patient and caregiver, is a global rating scale
designed for use in staging dementia. The primary objective of our study was to
examine the evolution of AD in individuals with very mild AD (CDR 0.5) across a
2-year follow up. METHODS: A cohort of AD patients (n = 682) living in the
community were followed during 2 years in 16 centres of the French AD network.
Each subject underwent extensive medical examination including the MMSE and CDR
every 6 months. RESULTS: Two hundred and thirty-three AD patients were rated CDR
0.5 at baseline (mean MMSE score: 23.15 +/- 2.57). They were younger and
reported an average duration of symptoms of approximately 0.8 years less than
patients with CDR >/= 1.During the 2-year follow-up, none of the AD CDR 0.5
subjects improved; 65% of them showed an increase in the CDR score. The rate of
cognitive decline was similar between the AD CDR 0.5 and CDR >/= 1 groups. The
ADL decline was more significant in patients with CDR >/= 1 at inclusion.
CONCLUSIONS: It is certainly possible to identify AD at a very early stage
focusing on intra individual change in cognitive and functional impairment.
Criteria with a high sensitivity and specificity for detecting AD at an early
stage will help to further develop effective pharmacological and behavioural
interventions for delaying the onset and progression of the disease. Copyright
(c) 2007 John Wiley & Sons, Ltd.
-----
Aging Ment Health. 2007 Sep;11(5):526-31.
Personality changes in Alzheimer's disease.
Talassi E, Cipriani G, Bianchetti A, Trabucchi M.
Department of Medicine, Istituto Clinico S. Anna, Hospital, Brescia, Italy.
Background: Assessment of personality changes in patients with dementia has
received little systematic investigation, although caregivers report personality
modifications in every phase of dementia. Methods: A group of 52 patients with
probable Alzheimer's disease (AD) vs. a group of fifteen control subjects were
selected for these personality tests before and after the manifestation of
dementia using an Italian version of Brooks and McKinaly's Personality Inventory
(PI). Results: After the onset of AD, a significant shift from positive to
negative characteristics in PI was observed in 12 of 18 bipolar pairs of
adjectives constituting the instrument and the total mean PI score decreased
significantly (p < 0.001), indicating a substantial worsening of personality
profile. In the control group however, evaluated before and after retirement,
personality traits and total mean PI score did not show a significant change.
The association of personality traits and total PI score with demographic,
cognitive and functional characteristics of AD patients was calculated.
Conclusion: Personality changes have been depicted to be influenced by severity
of cognitive, functional and behavioural complaints rather than age, sex,
education and disease duration. These first applications of the Italian version
of PI confirmed that personality modifications make a consistent aspect of the
phenomenology of AD although in the negative direction. Further studies are
needed to understand the nature of personality changes in dementia and the
utility of PI to investigate these changes.
-----
Int J Geriatr Psychiatry. 2007 Sep 18; [Epub ahead of print]
Quetiapine treatment for behavioural and psychological symptoms
of dementia in Alzheimer's disease patients: a 6-week, double-blind,
placebo-controlled study.
Paleacu D, Barak Y, Mirecky I, Mazeh D.
Neurology Service and Memory Clinic, Abarbanel Mental Health Center, Bat Yam,
Israel, Affiliated with the Sackler School of Medicine, Tel Aviv University,
Israel.
SETTING: Treating elderly patients with Alzheimer's disease (AD) and behavioral
and psychological symptoms of dementia (BPSD) is challenging due to the
increased risk of iatrogenic movement disorders with old neuroleptics and the
seemingly increasing risk of cardiovascular events with newer atypical agents.
Quetiapine is an atypical antipsychotic agent that warrants further
investigation. OBJECTIVES: To assess tolerability, safety, and clinical benefit
of quetiapine in AD patients with BPSD. PARTICIPANTS AND DESIGN: AD patients
with BPSD participated in a 6-week randomized, double-blind, placebo-controlled
trial. Quetiapine was increased on the basis of clinical response and
tolerability. Primary efficacy assessments included the Neuropsychiatric
Inventory (NPI) and Clinical Global Impression of Change (CGI-C). Secondary
efficacy measures included the Mini-Mental State Examination (MMSE), the
Simpson-Angus Scale (SAS) and the Abnormal Involuntary Movement Scale (AIMS).
RESULTS: Forty patients (26 women), mean age 82.2 (SD 6.4) years were enrolled,
27 completed treatment. Median dose of quetiapine was 200 mg/day. Significant
NPI total scores reductions (79% for placebo and 68.5% for quetiapine) were
observed. The CGI-C score decreased significantly in the quetiapine group (p =
0.009 at 6 weeks) and did not change significantly in the placebo group (p =
0.48). The MMSE, AIMS, SAS scores and adverse events did not differ
significantly between the two arms. CONCLUSIONS: Quetiapine did not
significantly improve psychosis scores. It did not cause cognitive and motor
deterioration. These results might possibly be due to small sample size.
Copyright (c) 2007 John Wiley & Sons, Ltd.
-----
J Alzheimers Dis. 2007 Sep;12(1):37-52.
One hundred years after the discovery of Alzheimer's disease. A
turning point for therapy?
Giacobini E, Becker RE.
Department of Rehabilitation and Geriatrics, University of Geneva Medical
School, Geneva, Switzerland.
Following the introduction of cholinesterase inhibitors in 1986 and a 20-yr long
period of successful clinical application in mild, moderate and severe patients,
the treatment of AD has turned to modify the course of pathological processes
thought to comprise the disease. Several active and passive vaccines are
presently under investigation for efficacy, reducing amyloid-beta in the brain
of patients with mild-moderately advanced disease. Three large international
immunization trials are in progress in US and Europe on mild-moderate AD
patients. Among these, the most advanced trial in time is the humanized antibody
trial. In addition, drugs aiming to reduce tauphosphorylation (GSK3 inhibitors)
are about to enter clinical phases of development. Due to intrinsic
difficulties, the developments of gamma-and beta-secretase inhibitors have not
yet reached clinical stages. Only one anti-amyloid-aggregation, an aminoglycan
compound, and one anti-APO-E approach with rosiglitazone are currently in
clinical testing. Stem-cell therapy and gene-replacing therapy remain
experimental and far from clinical application. Based on experimental evidence
that NGF (nerve growth factor) treatment could provide prolonged protection of
the central cholinergic system, i.c.v. infusion of NGF, with genetically
modified fibroblasts or gene therapy are under current investigation. NGF
treatment could probably double the clinical effect of ChEIs in time. Given the
level of scientific and clinical activity it is reasonable to expect that within
the next five to ten years a new therapy for AD will, by blocking disease
progression, both produce long term stabilization of at least 5 years in
patients with AD and prevent or delay emergence in persons at risk for AD.
-----
Neurology. 2007 Sep 11;69(11):1084-93.
Mediterranean diet and Alzheimer disease mortality.
Scarmeas N, Luchsinger JA, Mayeux R, Stern Y.
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia
University Medical Center, New York, NY 10032, USA. ns257@columbia.edu
BACKGROUND: We previously reported that the Mediterranean diet (MeDi) is related
to lower risk for Alzheimer disease (AD). Whether MeDi is associated with
subsequent AD course and outcomes has not been investigated. OBJECTIVES: To
examine the association between MeDi and mortality in patients with AD. METHODS:
A total of 192 community-based individuals in New York who were diagnosed with
AD were prospectively followed every 1.5 years. Adherence to the MeDi (0- to
9-point scale with higher scores indicating higher adherence) was the main
predictor of mortality in Cox models that were adjusted for period of
recruitment, age, gender, ethnicity, education, APOE genotype, caloric intake,
smoking, and body mass index. RESULTS: Eighty-five patients with AD (44%) died
during the course of 4.4 (+/-3.6, 0.2 to 13.6) years of follow-up. In unadjusted
models, higher adherence to MeDi was associated with lower mortality risk (for
each additional MeDi point hazard ratio 0.79; 95% CI 0.69 to 0.91; p = 0.001).
This result remained significant after controlling for all covariates (0.76;
0.65 to 0.89; p = 0.001). In adjusted models, as compared with AD patients at
the lowest MeDi adherence tertile, those at the middle tertile had lower
mortality risk (0.65; 0.38 to 1.09; 1.33 years' longer survival), whereas
subjects at the highest tertile had an even lower risk (0.27; 0.10 to 0.69; 3.91
years' longer survival; p for trend = 0.003). CONCLUSION: Adherence to the
Mediterranean diet (MeDi) may affect not only risk for Alzheimer disease (AD)
but also subsequent disease course: Higher adherence to the MeDi is associated
with lower mortality in AD. The gradual reduction in mortality risk for higher
MeDi adherence tertiles suggests a possible dose-response effect.
-----
Curr Neurol Neurosci Rep. 2007 Sep;7(5):366-372.
Diet and Alzheimer's Disease.
Luchsinger JA, Noble JM, Scarmeas N.
Taub Institute for Research of Alzheimer’s Disease and the Aging Brain, Columbia
University, PH9E-105, 630 West 168th Street, New York, NY 10032, USA. jal94@columbia.edu.
Alzheimer's disease (AD) is increasing in prevalence. There are no known
preventive or curative measures. There is evidence that oxidative stress, homo-cysteine-related
vitamins, fats, and alcohol have a role in the pathogenesis of AD. Some
epidemiologic studies suggest that higher dietary intake of antioxidants,
vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related
to a lower risk of AD, but reports are inconsistent. Modest to moderate alcohol
intake, particularly wine, may be related to a lower risk of AD. The
Mediterranean diet may also be related to lower AD risk. However, randomized
clinical trials of supplements of vitamins E, B(12), B(6), and folate have shown
no cognitive benefit, and randomized trials for other nutrients or diets in AD
are not available. The existing evidence does not support the recommendation of
specific supplements, foods, or diets for the prevention of AD.
-----
Aging Clin Exp Res. 2007 Aug;19(4):316-22.
Cognitive stimulation intervention for elders with mild cognitive
impairment compared with normal aged subjects: preliminary results.
Wenisch E, Cantegreil-Kallen I, De Rotrou J, Garrigue P, Moulin F, Batouche F,
Richard A, De Sant'anna M, Rigaud AS.
Department of Gerontology, Broca Hospital, 75013 Paris, France. emilie.wenisch@brc.aphp.fr.
BACKGROUND AND AIMS: Cognitive training programs have been developed for
Alzheimer's disease patients and the healthy elderly population. Collective
cognitive stimulation programs have been shown to be efficient for subjects with
memory complaint. The aim of this study was to evaluate the benefit of such
cognitive programs in populations with Mild Cognitive Impairment (MCI). METHODS:
Twelve patients with MCI and twelve cognitively normal elders were administered
a cognitive stimulation program. Cognitive performance (Logical Memory, Word
paired associative learning task, Trail Making Test, verbal fluency test) were
collected before and after the intervention. A gain score [(post-score -
prescore)/pre-score] was calculated for each variable and compared between
groups. RESULTS: The analysis revealed a larger intervention size effect in MCI
than in normal elders' performances on the associative learning task (immediate
recall: p<0.05, delayed recall: p<0.01). The intervention was more beneficial in
improving associative memory abilities in MCI than in normal subjects. At the
end of the intervention, the MCI group had lower results than the normal group
only for the delayed recall of Logical Memory. CONCLUSIONS: Although further
studies are needed for more details on the impact of cognitive stimulation
programs on MCI patients, this intervention is effective in compensating
associative memory difficulties of these patients. Among non-pharmacological
interventions, cognitive stimulation therapy is a repeatable and inexpensive
collective method that can easily be provided to various populations with the
aim of slowing down the rate of decline in elderly persons with cognitive
impairment.
-----
Neurology. 2007 Aug 28;69(9):878-85.
Statin therapy is associated with reduced neuropathologic changes
of Alzheimer disease.
Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind
MA, Breitner JC, Montine TJ.
Department of Psychiatry and Behavioral Sciences, University of Washington,
Seattle, WA, USA. gli@u.washington.edu
BACKGROUND: Treatment with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase
inhibitors ("statins") has been associated in some epidemiologic studies with
reduced risk of Alzheimer disease (AD). However, direct evidence of statin
effects on neuropathologic markers of AD is lacking. We investigated whether
antecedent statin exposure is associated with neuritic plaque (NP) or
neurofibrillary tangle (NFT) burden in a population-based sample of human
subjects. METHODS: Brain autopsies were performed on 110 subjects, ages 65 to 79
years, who were cognitively normal at enrollment into the Adult Changes in
Thought Study. Neuropathologic findings were compared between statin users with
> or =3 prescriptions of > or =15 pills of simvastatin, pravastatin, lovastatin,
or atorvastatin vs nonusers, based on pharmacy dispensing records. RESULTS:
After controlling for age at death, gender, cognitive function at study entry,
brain weight, and presence of cerebral microvascular lesions, the odds ratio
(OR) for each unit increase in Braak NFT stage in statin users vs nonusers was
0.44 (95% CI: 0.20 to 0.95). The OR for each unit increase in Consortium to
Establish a Registry for Alzheimer's Disease (CERAD) staging of NPs did not
deviate significantly from unity (OR 0.69; 95% CI: 0.32 to 1.52). However, the
risk for typical AD pathology (Braak stage > or = IV and CERAD rating > or =
moderate) was reduced in statin users (OR 0.20; 95% CI: 0.05 to 0.86).
CONCLUSIONS: These findings demonstrate an association between antecedent statin
use and neurofibrillary tangle burden at autopsy. Additional study is needed to
examine whether statin use may be causally related to decreased development of
Alzheimer disease-related neuropathologic changes.
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Am J Psychiatry. 2007 Jun;164(6):910-915.
Nursing Home Placement, Day Care Use, and Cognitive Decline in
Alzheimer's Disease.
Wilson RS, McCann JJ, Li Y, Aggarwal NT, Gilley DW, Evans DA.
Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 S. Paulina
St., Suite 1038, Chicago, IL 60612. rwilson@rush.edu.
OBJECTIVE: People with Alzheimer's disease are often placed in a nursing home,
sometimes after using adult day care services. How affected persons function
during this potentially difficult transition is not well understood. The aim of
this study was to examine the associations of day care use and nursing home
placement with the rate of cognitive decline in Alzheimer's disease. METHOD: The
participants were 432 older persons with Alzheimer's disease who were recruited
from health care settings in the Chicago area. At baseline, they lived in the
community and were using day care services a mean 1.7 days per week. At 6-month
intervals for up to 4 years, they completed nine cognitive tests from which a
composite measure of global cognition was derived. RESULTS: On average,
cognition declined at a gradually increasing rate during the study period.
Nursing home placement was associated with a decrease in the level of cognition
and an acceleration in the rate of cognitive decline. Day care use at baseline
was not related to cognitive decline in initial analyses, but it interacted with
nursing home placement such that higher level of day care use substantially
reduced association of placement with accelerated cognitive decline. Education
interacted with placement such that more schooling was associated with a greater
increase in cognitive decline upon nursing home placement, but prior day care
use also attenuated this association. CONCLUSIONS: Nursing home placement is
associated with accelerated short-term cognitive decline in Alzheimer's disease.
Prior experience in adult day care may lessen this association.
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Dtsch Med Wochenschr. 2007 Jun 1;132(22):1207-13.
[Cholinesterase inhibitors and Alzheimer's disease: demonstrable
efficacy, origin and bias of published studies.]
[Article in German]
Egert S, Wagenpfeil S, Förstl H.
Münchner Studienzentrum.
BACKGROUND AND OBJECTIVE: The cholinesterase-inhibitors (AChE-I) donepezil,
galantamine and rivastigmine are currently used in the symptomatic treatment of
patients with Alzheimer's dementia (AD) and the associated cholinergic deficits
as well as those with other forms of dementia. Threee aspects were analysed: (1)
data on their clinical efficacy, (2) differences between North-American and
international studies, and (3) potential publication biases. METHODS: Included
were data from randomized, placebo-controlled, double-blind parallel group
trials on more than 100 patients who had been treated for >/=12 weeks for AD,
VaD, dementia with Lewy bodies, dementia with Parkinson's disease or with mild
cognitive impairment. RESULTS: These large published trials support the clinical
efficacy of AChE-I in patients with mild to moderate AD and other forms of
dementia with regard to cognition and global impression. there was a trend
towards greater beneficial cognitive effects in North-American studies, but this
was non-significant. There was no evidence of a publication bias. CONCLUSIONS:
Published data provide evidence for the clinical efficacy of donepezil,
galantamine and rivastigmine in patients with mild to moderate AD. There is no
indication that these results are critically influenced by the origin or a bias
of the publication.
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Expert Opin Investig Drugs. 2007 Jun;16(6):819-28.
Clinical immunologic approaches for the treatment of Alzheimer's
disease.
Solomon B.
George S. Wise Faculty of Life Sciences, Department of Molecular Microbiology &
Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. beka@post.tau.ac.il
Recent clinical trials of active vaccination against beta-amyloid (Abeta) have
succeeded in clearing Abeta plaques; however, further understanding of
immunization with regards to inflammation and other hallmarks of Alzheimer's
disease pathology is required. Antibodies generated with this first-generation
vaccine may not have had the desired therapeutic properties or targeted the
'correct' mechanism, but they have opened the way for new clinical approaches,
which are now under consideration. Passive administration of monoclonal
antibodies directed to various regions of Abeta peptide and/or administration of
immunoconjugates of only small fragments of the N-terminal region may lead to
the development of an improved second generation of Abeta vaccines. Amyloid
immunotherapy offers genuine opportunities for disease treatment; however, such
an approach towards treating and preventing Alzheimer's disease patients
requires careful antigen and antibody selection to maximize efficacy and
minimize adverse events.
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Expert Opin Pharmacother. 2007 May;8(7):1011-23.
Donepezil: an update.
Seltzer B.
V.A. Boston Healthcare System, Department of Neurology, Harvard Medical School,
Geriatric Research Center, Boston, MA 02130, USA. bseltzer@partners.org
Donepezil hydrochloride is the most widely prescribed drug for Alzheimer's
disease (AD). The main mechanism of action through which it influences cognition
and function is presumed to be the inhibition of acetylcholinesterase enzyme in
the brain; however, donepezil may also impact the pathophysiology of AD at
several other points. Officially approved for mild-to-moderate and severe AD,
donepezil has also been shown to be effective in early-stage AD, vascular
dementia, Parkinson's disease dementia/Lewy body disease and cognitive symptoms
associated with multiple sclerosis. In addition, one study suggested that
donepezil may delay the onset of AD in subjects with mild cognitive impairment,
a prodrome to AD. The pharmacokinetics, pharmacodynamics, safety/tolerability
profile and drug interaction properties of donepezil make it an easy and safe
agent to use. However, in general, the efficacy of donepezil is limited, and
ongoing studies are investigating other agents that may ultimately overtake its
present position as the mainstay of anti-AD therapy.
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Neurology. 2007 May 1;68(18):1509-14.
Cognitive decline in Alzheimer disease: Impact of spirituality,
religiosity, and QOL.
Kaufman Y, Anaki D, Binns M, Freedman M.
Behavioural Neurology Program, Division of Neurology, Baycrest, Canada. ykaufman@herzoghospital.org
OBJECTIVE: To assess effects of quality of life (QOL), spirituality, and
religiosity on rate of progression of cognitive decline in Alzheimer disease
(AD). METHODS: In this longitudinal study, we recruited 70 patients with
probable AD. The Mini-Mental State Examination was used to monitor the rate of
cognitive decline. Religiosity and spirituality were measured using standardized
scales that assess spirituality, religiosity, and organizational and private
religious practices. We conducted a simultaneous multiple linear regression
analysis for factors contributing to rate of cognitive decline. RESULTS: After
controlling for baseline level of cognition, age, sex, and education, a slower
rate of cognitive decline was associated with higher levels of spirituality (p <
0.05) and private religious practices (p < 0.005). These variables accounted for
17% of the total variance [F(11,58) = 2.24, p < 0.05]. There was no correlation
between rate of cognitive decline and QOL. CONCLUSION: Higher levels of
spirituality and private religious practices, but not quality of life, are
associated with slower progression of Alzheimer disease.
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Int J Geriatr Psychiatry. 2007 May;22(5):475-84.
The efficacy and safety of risperidone in the treatment of
psychosis of Alzheimer's disease and mixed dementia: a meta-analysis of 4
placebo-controlled clinical trials.
Katz I, de Deyn PP, Mintzer J, Greenspan A, Zhu Y, Brodaty H.
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
BACKGROUND: Dementia typically includes behavioral and psychological symptoms of
dementia (BPSD) as well as cognitive decline. Psychosis of Alzheimer's disease
(AD) is a specific component of AD, characterized by delusions,
misidentifications, and hallucinations. METHODS: This study is a meta-analysis
of patients with psychosis of AD from four large placebo-controlled clinical
trials of risperidone in dementia. Three trials included patients diagnosed with
heterogeneous symptoms of BPSD (those with psychosis of AD were included in this
analysis), while one trial included only those diagnosed with psychosis of AD.
Efficacy was measured using the Behavioral Pathology in Alzheimer's Disease
(BEHAVE-AD) Psychosis subscale and Clinical Global Impression (CGI). RESULTS:
Primary analyses in the psychosis of AD population demonstrated that risperidone
significantly improved scores on the BEHAVE-AD Psychosis subscale and CGI scale
compared with placebo. Secondary analyses demonstrated that patients with more
severe symptoms showed a more pronounced response to treatment with risperidone
compared with placebo than those patients with less severe symptoms.
Extrapyramidal symptoms and somnolence were more frequent with risperidone than
placebo (p = 0.04). Cerebrovascular adverse events and all-cause mortality were
observed more frequently, although not statistically significantly, with
risperidone versus placebo. CONCLUSIONS: This meta-analysis of psychosis of AD
showed improvement in psychotic symptoms and general clinical improvement in
patients with psychosis of AD treated with risperidone compared with placebo.
The benefits of treatment were most significant in patients with severe
symptoms. The safety profile of risperidone in this psychosis of AD population
was similar to the more general BPSD population. Copyright (c) 2007 John Wiley &
Sons, Ltd.
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Can J Psychiatry. 2007 Apr;52(4):248-55.
Efficacy and safety of antidepressants for treatment of
depression in Alzheimer's disease: a metaanalysis.
Thompson S, Herrmann N, Rapoport MJ, Lanctôt KL.
Department of Psychiatry, Atlantic Health Sciences Corporation, Saint John, New
Brunswick.
OBJECTIVE: Depression in patients with Alzheimer's disease (AD) is common (15%
to 63%) and is associated with significant morbidity and increased mortality.
Our objective was to quantitatively summarize the data on the efficacy and
safety of antidepressant treatment for depression complicating AD. METHOD: We
performed a metaanalysis of randomized, double-blind, placebo-controlled trials
of antidepressants with a database search of the English literature (up to 2006)
and a manual search of references in the retrieved articles. We extracted the
proportion of subjects who responded and remitted, experienced adverse events (AEs),
discontinued treatment due to AEs, or discontinued treatment for any reason.
Cognition scores were also extracted. RESULTS: We included 5 studies, which
involved 82 subjects treated with antidepressants and 83 subjects who received
placebo treatment. Antidepressants were superior to placebo for both treatment
response (odds ratio [OR] 2.32; 95% confidence interval [CI], 1.04 to 5.16) and
remission of depression (OR 2.75; 95% CI, 1.13 to 6.65). There were no
significant differences between the 2 groups for change in cognition (weighted
mean difference -0.71, 95% CI, -3.20 to 1.79), overall dropouts (OR 0.70; 95%
CI, 0.29 to 1.66) or dropout due to AEs (OR 1.41; 95% CI 0.36 to 5.54). The
numbers needed to treat for one additional AD patient to respond to
antidepressant treatment were 5 (95% CI, 3 to 59) and 5 (95% CI, 2 to 24) for
remission of depression. CONCLUSIONS: Antidepressant treatment for depression in
AD is efficacious, with rates of discontinuation that are comparable to placebo.
Nonetheless, clinicians must be vigilant regarding the potential side effects of
antidepressants in this population.
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Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):62-77.
Language-enriched exercise plus socialization slows cognitive
decline in Alzheimer's disease.
Arkin S.
Department of Speech and Hearing Sciences), University of Arizona, Tucson, USA.
arkinaz@earthlink.net
This article reports the effects of language-enriched physical fitness
interventions provided by University of Arizona undergraduate students to 24
mild- to moderate-stage Alzheimer's disease patients (AD Rehab group).
Socialization experiences consisted of supervised volunteer work and
cultural/recreational activities. Changes in global functioning and
neuropsychological test performance were tracked and compared to those of a
similar group of untreated patients from the Consortium for the Establishment of
a Registry for Alzheimer's Disease (CERAD). Cohorts completing 4 semesters or
longer showed no significant between-year changes after their first year on the
Clinical Dementia Rating, a measure of global functioning, and on 5 or 6 of the
cognitive and language measures. Comparisons with the CERAD sample suggested a
slower rate of decline for the AD Rehab group. The stabilization of global and
cognitive performance was not apparent among participants who completed only 2
semesters. Significant physical fitness and mood outcomes were previously
reported in this journal.
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Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):42-7.
Cognitive and psychopathologic response to rivastigmine in
dementia with Lewy bodies compared to Alzheimer's disease: a case control study.
Rozzini L, Chilovi BV, Bertoletti E, Conti M, Delrio I, Trabucchi M, Padovani A.
Department of Neurology, University of Brescia, Italy. lrozzini@iol.it
Cholinesterase inhibitors (ChEIs) are effective in improving cognition and
behavior in patients affected by Alzheimer's disease (AD) as well as by Lewy
bodies dementia (DLB). The authors compared the effect of rivastigmine in the
treatment of cognitive impairment and behavioral and psychological symptoms of
dementia (BPSD) in 30 AD and in 30 DLB patients. At baseline, DLB compared to AD
patients showed a greater number of extrapyramidal symptoms (P < .005) and were
similar regarding cognitive symptoms and BPSD. After treatment, both groups
showed a comparable cognitive and psycho-behavioral improvement. A significant
difference between AD and DLB patients was found for hallucinations (P < .002).
Rivastigmine produces comparable cognitive benefits in patients with DLB and AD
and also a significant improvement of behavioral disorders. These findings
support the view that ChEIs should be considered a first-line treatment of the
cognitive and psycho-behavioral symptoms of both AD and DLB.
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Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):14-9.
Effectiveness of support groups for people with mild to moderate
Alzheimer's disease: an evaluative survey.
Snyder L, Jenkins C, Joosten L.
University of California, San Diego, Shiley-Marcos Alzheimer's Disease Research
Center, 9500 Gilman Drive 0948, La Jolla, CA 92093, USA. lsnyder@ucsd.edu
Support groups can provide a forum for socialization and learning for people
with mild to moderate Alzheimer's disease. The aim of this study was to evaluate
the effectiveness of these groups based on participant feedback. A survey
questionnaire was administered to 70 support group participants with Alzheimer's
disease from 8 well-established groups across the United States. Participants
reported on the educational value, positive socialization, and improved ability
to cope with symptoms and to accept the diagnosis as a result of participating
in a support group. These reported outcomes suggest the importance of creating
more sensitive measures to better evaluate the effectiveness of support groups
and other educational or social support programs for persons with dementia.
-----
CNS Spectr. 2007 Feb;12(2):119-23.
Alzheimer's Disease: Progress in the Development of Anti-amyloid
Disease-Modifying Therapies.
Christensen DD.
University of Utah, Salt Lake City, UT, USA.
The amyloid hypothesis-the leading mechanistic theory of Alzheimer's
disease-states that an imbalance in production or clearance of amyloid beta (Abeta)
results in accumulation of Abeta and triggers a cascade of events leading to
neurodegeneration and dementia. The number of persons with Alzheimer's disease
is expected to triple by mid-century. If steps are not taken to delay the onset
or slow the progression of Alzheimer's disease, the economic and personal tolls
will be immense. Different classes of potentially disease-modifying treatments
that interrupt early pathological events (ie, decreasing production or
aggregation of Abeta or increasing its clearance) and potentially prevent
downstream events are in phase II or III clinical studies. These include
immunotherapies; secretase inhibitors; selective Abeta42-lowering agents;
statins; anti-Abeta aggregation agents; peroxisome proliferator-activated
receptor-gamma agonists; and others. Safety and serious adverse events have been
a concern with immunotherapy and gamma-secretase inhibitors, though both
continue in clinical trials. Anti-amyloid disease-modifying drugs that seem
promising and have reached phase III clinical trials include those that
selectively target Abeta42 production (eg, tarenflurbil), enhance the activity
of alpha-secretase (eg, statins), and block Abeta aggregation (eg, transiposate).
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Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):135-141.
A brief review of the pharmacologic and therapeutic aspects of
memantine in Alzheimer's disease.
Schmitt F, Ryan M, Cooper G.
1University of Kentucky, Sanders-Brown Center on Aging, and Department of
Neurology, and Departments of Psychiatry, Psychology, and Behavioural Sciences,
800 S. Limestone Street, Lexington, KY 40536-0230, USA. fascom@email.uky.edu ,
2University of Kentucky, Department of Neurology, and Department of Pharmacy
Practice and Science, 800 S. Limestone Street, Lexington, KY 40536-0230, USA,
3University of Kentucky, Sanders-Brown Center on Aging, and Department of
Neurology, 800 S. Limestone Street, Lexington, KY 40536-0230, USA, 4Lexington
Clinic, Division of Neurology, Lexington, KY, USA.
The past decade has seen an increase in therapeutic options for Alzheimer's
disease (AD) that target neurotransmitters, such as acetylcholine, and research
continues to target abnormal proteins in the AD brain. Recently, glutamate
excitotoxicity has also become a target for AD treatment with the advent of
memantine. Clinical trial data reviewed for memantine show good tolerability,
low side-effect profiles and a positive therapeutic impact in moderate-to-severe
AD, both as monotherapy and in conjunction with donepezil. However, additional
data suggest variable benefits in the mild stages of AD. Furthermore, published
reports support reduced dosing in patients with significant renal disease.
However, the opportunity to target a second mechanism in the treatment of AD,
thereby providing added symptomatic benefit, appears to be a useful
consideration for clinicians who treat this devastating neurodegenerative
disorder.
-----
Expert Opin Pharmacother. 2007 Feb;8(2):203-14.
Memantine in the treatment of mild-to-moderate Alzheimer's
disease.
Cosman KM, Boyle LL, Porsteinsson AP.
University of Rochester School of Medicine, Alzheimer's Disease Care Research
and Education Program (AD-CARE), Monroe Community Hospital, 435 East Henrietta
Road, Rochester, NY 14620, USA. Kelly_Cosman@urmc.rochester.edu
Memantine is the first and only medication that has been approved by European,
US and Canadian regulatory agencies for the treatment of moderate-to-severe
Alzheimer's disease (AD). It is an NMDA receptor antagonist that works to
prevent excitotoxicity and cell death, which are mediated by the excessive
influx of calcium during a sustained release of glutamate. Preclinical studies
of memantine reveal that it has the potential to improve memory and learning
processes after impairment has occurred, as well as to prevent further neuronal
damage. Although memantine has been considered for the treatment of earlier AD,
it has not yet been approved for this. Randomized controlled trials of memantine
in the treatment of mild-to-moderate AD have demonstrated small treatment
effects in measures of cognition, global assessment and behavior favoring the
use of memantine. However, the differences between treatment groups were not
consistently significant. Two ongoing long-term trials are further investigating
the efficacy of memantine in the treatment of mild-to-moderate AD.
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Dement Geriatr Cogn Disord. 2007 Jan 25;23(3):194-201 [Epub ahead of print]
Prevention and Treatment of Dementia or Alzheimer's Disease by
Statins: A Meta-Analysis.
Zhou B, Teramukai S, Fukushima M.
Division of Clinical Trial Design and Management, Translational Research Center,
Kyoto University Hospital, Kyoto, Japan.
Background/Aim: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins)
are thought to reduce the amount of Abeta peptides by reducing cholesterol from
blood and/or cerebrospinal fluid. We performed this meta-analysis to evaluate
the preventive and treatment effects of statins on dementia and Alzheimer
disease onset. Methods: Relevant studies were systematically identified, and
data were abstracted according to predefined criteria. We used a fixed-effects
model and a random-effects model to compute pooled relative risks and to assess
statistical heterogeneity. Results: The pooled crude odds ratios in statin users
as compared with nonusers were 0.67 (95% confidence interval CI 0.54-0.82) in
the dementia group and 0.81 (95% CI 0.64-1.02) in the Alzheimer group. The
pooled adjusted relative risks calculated by random-effects model were 0.77 (95%
CI 0.45-1.30) in the dementia group and 0.81 (95% CI 0.56-1.16) in the Alzheimer
group. Conclusions: Statin use did not show a beneficial effect on the risk of
dementia or Alzheimer's disease. Further study and independent confirmation of
the association between statin use and dementia and Alzheimer's disease in
larger clinical trials are warranted. Copyright (c) 2007 S. Karger AG, Basel.
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Am J Alzheimers Dis Other Demen. 2007 December-January;21(6):454-459.
Clock Drawing and Frontal Lobe Behavioral Effects of Memantine in
Alzheimer's Disease: A Rater-Blinded Study.
Paskavitz JF, Gunstad JJ, Samuel JE.
Department of Neurology, University of Massachusetts Medical School, Worcester,
Massachusetts. James.Paskavitz@Perceptive.com.
Caregivers of Alzheimer's disease patients treated with memantine have reported
improved frontal lobe behaviors. The present study examined these possible
improvements in executive functioning using rater-blinded scoring of a
clock-drawing test. Fifty-one Alzheimer's disease patients were treated with
open-label memantine for 10 weeks. Clock drawing and Mini-Mental State
Examination data were collected before and after treatment. Clock drawing
improved significantly with treatment, whereas Mini-Mental State Examination
data did not. Twenty-seven patients judged as improved in frontal lobe behaviors
by caregivers demonstrated a statistically significant improvement in clock
drawing to command, whereas 24 patients judged to be unchanged or worse with
memantine in their frontal lobe behaviors had no change in their clock drawing
and had worsening on their Mini-Mental State Examination. The current findings
suggest that memantine improves frontal lobe behavior in some Alzheimer's
disease patients and that clock drawing to command may be sensitive to these
improvements.
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Am J Alzheimers Dis Other Demen. 2007 December-January;21(6):448-453.
Efficacy and Tolerability of Quetiapine in the Treatment of
Behavioral and Psychological Symptoms of Dementia.
Onor ML, Saina M, Aguglia E.
University of Trieste, Italy. marialuisa.onor@libero.it.
Behavioral symptoms start to appear in mild and moderate dementia and become
increasingly severe with the progression of the disease. Agitation,
aggressiveness, and psychosis can be seen in Alzheimer's disease, and in
particular are common manifestations in Lewy body dementia. It is the behavioral
disturbances rather than the cognitive disorders that are more often the cause
of the institutionalization of these patients because of the heavy assistance
and emotional burden they represent for caregivers. Traditionally, these kinds
of symptoms were controlled by classical antipsychotic agents, which after
long-term use cause severe extrapyramidal effects, late dyskinesia, sedation,
orthostatic hypotension, and cognitive function impairment. More recently,
atypical antipsychotic agents have shown a better tolerability profile, with a
reduced incidence of extrapyramidal effects, orthostatic hypotension, sedation,
and a reduced impact on cognitive function. The aim of this study is to evaluate
the efficacy and tolerability of quetiapine in a group of patients with a
diagnosis of dementia and concomitant psychotic disorders. The response to
treatment was evaluated by the Neuropsychiatric Inventory (NPI) and the
Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). The NPI
and BEHAVE-AD were administered at baseline and after 4 weeks and 12 weeks of
therapy. Tolerability was assessed by the incidence of clinically evident side
effects. The results show that quetiapine is effective in reducing behavioral
symptoms, deliria and hallucinations, aggressiveness, and sleep disturbances.
Quetiapine tolerability proved to be satisfactory. The only side effect of
clinical significance was orthostatic hypotension, which was, however, partially
preventable by a slower drug titration.
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Curr Top Med Chem. 2007;7(1):115-26.
Disrupting beta-Amyloid Aggregation for Alzheimer Disease
Treatment.
Estrada LD, Soto C.
Protein Misfolding Disorders Laboratory, George and Cynthia Mitchell Center for
Alzheimer's disease research, Department of Neurology and Neurosciences and Cell
Biology, University of Texas Medical Branch, Galveston, TX, USA. clsoto@utmb.edu.
Alzheimer's disease is a devastating degenerative disorder for which there is no
cure or effective treatment. Although the etiology of Alzheimer's disease is not
fully understood, compelling evidence indicates that deposition of aggregates
composed by a misfolded form of the amyloid beta peptide (Abeta) is the central
event in the disease pathogenesis. Therefore, an attractive therapeutic strategy
is to prevent or reverse Abeta misfolding and aggregation. Diverse strategies
have been described to identify inhibitors of this process, including screening
of libraries of small molecules chemical compounds, rational design of synthetic
peptides, assessment of natural Abeta-binding proteins and stimulation of the
immune system by vaccination. In this article we describe these different
approaches, their principles and their potential strengths and weaknesses.
Overall the available data suggest that the development of drugs to interfere
with Abeta misfolding and aggregation is a feasible target that hold great
promise for the treatment of Alzheimer's disease.
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